Make anticancer drugs active again
- Time extension of anticancer drug using
- Efflux inhibition of anticancer agents
- Improvement of the efficiency and comfort of the chemotherapy
- Multidrug resistance
- 1 patent
Partnerships & Rewards
- Région Auvergne-Rhône-Alpes
- i-PhD winner - 2021
Cancer is a major health issue with growing economic impact, supported by our society. These are two reasons why the research for long-term and effective new treatments is constantly evolving and funded by numerous sources of funding.
The CHEMRES project aims to develop an active, selective, and non-toxic inhibitor of a protein involved in multidrug resistance to chemotherapy. Its therapeutic potential should be reached when used in combination with an anticancer drug.
Multidrug resistance is one of the main causes of chemotherapy failure. Restoring tumour cells sensitivity to treatment would make chemotherapy more effective while reducing the number of side and/or adverse effects as well as the cost and duration of treatment.
State of progress
Preliminary in vitro studies have allowed us to identify a series of molecules of therapeutic interest. Their synthesis was scaled-up for a production of several grams in order to start the steps of formulation and biological evaluation in vivo.
We are considering a therapeutic protocol which would be to use a combination of our inhibitor and an anticancer drug in order to allow the latter to overcome the acquired resistance and thus fully restore its effectiveness. In addition, our molecules being selective, they could serve as a diagnostic tool.
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