APIOS | Linksium
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Stimulates bone regeneration

profilePhoto   Chloé Poyet
Linksium Contact Chloé Poyet +33 (0)6 46 57 42 17 chloe.poyet@linksium.fr
150020 APIOS


  • Osteoinductor film easy to produce and use

Key words

  • Implants
  • Osteoinduction
  • Osteoconduction
  • Biopolymers

Intellectual Property

  • 2 patents


  • LMGP


  • CNRS

Linksium Continuum

  • Maturation
  • Incubation


The repair of major bone defects of critical size remains a challenge in orthopaedic, maxillo-facial and dental surgery. The reference technique is still the autologous bone graft, but this is limited in terms of the quantity of material available and, in particular, is very painful for the patient. Implantable biomaterials with a metal, polymer or ceramic base are an alternative, but they must be optimised for their performance to be improved. In fact, none of these implants is capable of actively stimulating the stem cells we have in our bodies.


APIOS is a bioactive film comprised of natural polymers, which makes it possible to store an active principle (bone morphogenetic proteins) locally, accelerating bone regeneration and improving the integration of implants. This film is potentially usable on all types of implant regardless of their nature and shape (screw, cage, etc.).


The film has a strong capacity to retain bioactive proteins and makes it possible to regulate the amount of protein being dispensed. It actively stimulates bone regeneration.
It is applied locally to the surface of the implant, enabling a significant reduction in the dose required for the bone regeneration of the injury site.
The film can be dried and stored for at least two years; it can be sterilised by gamma irradiation. The bioactive film retains its bioactivity for at least one year.

State of progress

A full characterisation of the film was carried out using physico-chemical and microscopic techniques on different spatial scales. Its production, sterilisation and dry storage are established and reproducible.
Evidence of the film’s osteoinduction at ectopic and bone sites was established on small animals (mice, rats), and tests on large animals are in progress. The current technological and pre-clinical development mean that clinical tests can be planned in the medium term.


  • Maxillo-facial surgery
  • Orthopaedic and spinal surgery
  • Dental surgery
  • Repair of injuries
  • Biomaterials