RBP-CAPTURE | Linksium
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The full potential of RNA for purification

profilePhoto   Laurène El Bahhaj
Linksium Contact Laurène El Bahhaj +33 (0)7 76 23 29 19 laurene.elbahhaj@linksium.fr


  • Fast and simple
  • More specificity and purity
  • Increased yield
  • Low cost

Key words

  • Protein purification
  • Protein-RNA interaction
  • Protein immobilization
  • Bio-production

Intellectual Property

  • 1 patent

Partnerships & Rewards

  • 2022 i-PhD French Deeptech Innovation Competition Winner


  • IAB


  • CNRS
  • UGA

Linksium Continuum

  • Maturation


The world market for protein purification is constantly increasing and purification techniques are mainly based on affinity processes such as antigen-antibody interactions or ionic interactions. These processes have the advantage of being robust and well mastered by the industry, but they have several drawbacks and technical limitations that can be problematic.


The innovation at the heart of the RBP-Capture technology lies in the exploitation of a unique and highly specific interaction between the RBP-C protein and an RNA. In this technology, RBP-C is fused to the protein of interest to allow its purification. This purification is done by means of a bait RNA itself bound to a resin.


  • Purify without the addition of antibodies, thus reducing the cost of purification
  • High purification yield
  • High specificity in the recognition of the protein to be purified
  • Single step purification, reducing process time

State of progress

The first phases of development allowed a comparative study against two widely used purification techniques on the market (i.e. TAP tag purification and antibody purification). Initial results show that RBP-Capture is at least as efficient as TAP purification of the same protein, and that it greatly improves purity and purification yield compared to antibody purification.


RBP-Capture meets several application needs:

  • Research tool (public or private)
  • Bio-production
  • Simultaneous purification
  • Enzyme immobilization

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