BRAINPEPS | Linksium
Back to portfolio

BRAINPEPS

Maturation

A new cell penetrating peptide to cross the blood brain barrier

profilePhoto   Elodie Lages
Linksium Contact Elodie Lages +33 (0)7 76 23 29 19 elodie.lages@linksium.fr
BBB image

Benefits

  • Blood brain barrier crossing
  • Increase in the crossing rate of molecules
  • Plug and play conjugation

Key words

  • Blood brain barrier crossing
  • Cell Penetrating Peptide
  • Brain and CNS diseases

Intellectual Property

  • 1 patent

Laboratory

  • LRB

Institutions

  • CEA
  • CNRS
  • UGA

Linksium Continuum

  • Maturation

Results

  • Available licenses

Context

Crossing the blood-brain barrier (BBB) is the biggest obstacle to the development of new drugs with brain targets.

The majority of drug candidates for a central nervous system disease are abandoned in the clinical phase because they fail to reach their target.

Technology

BRAINPEPS' technology has developed a cell-penetrating peptide (CPP) that can be used in a plug-and-play manner using a cross-linker and that promotes the passage of the BBB to allow drug candidates to reach their brain target.

Advantages

  • An innovative CPP, whose three-dimensional conformation has been optimized for the passage of the BBB
  • Increase in BBB passage by +10x compared to other known CPPs
  • Diversity of application with a coupling system via a cross linker.

State of progress

  • Chemical grafting of the cell penetrating peptide to the brain-targeted drug candidate or production of the fusion protein.
  • Evaluation of toxicity and efficacy of passage on a differentiated cell blood-brain barrier model in comparison with other solutions.
  • Evaluation of brain penetration in vivo after intravenous injection in mice using the conjugation of CPP BRAINPEPS with a temperature biosensor (neurotensine).
  • System and model ready for efficacy testing with drug candidates: first underway with a nanobody in a tauopathy application.

Applications

The applications concern all nervous system pathologies whose management requires the passage of molecules of interest across the BBB. They also cover the development of brain biomarkers for these diseases.

  • Neurological diseases (Alzheimer's, Parkinson's, etc)
  • Pain management
  • Glioblastoma
  • Psychiatric diseases

Featured articles

Nora Dempsey and deeptech innovations

1, 2 and 3 startups for Nora Dempsey, National Medal of Innovation 2021

Nora Dempsey is one of the four winners of National Medal for Innovation 2021 awarded by CNRS. Nora Dempsey, born in Ireland, has gained an international recognition for her research in Grenoble on...

Read the article
Dd amiral 2018 Frenchweb

Amiral Technologies, la startup IA grenobloise spécialisée dans les solutions de maintenance prédictive, intègre Station F

An ambitious promise: to invent a zero-defect and zero-downtime future for industry. Amiral Technologies, a startup co-founded and boosted by Linksium, based on the technological prowess of the Gre...

Read the article
Close projects index

U

X