OXUP | Linksium
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Breathe is live

profilePhoto   Christine Melay
Linksium Contact Christine Melay +33 (0)6 21 77 19 90 christine.melay@linksium.fr
110033 OXUP


  • Easy to use, light and non-drug solution to reduce AMS (Acute Mountain Sickness)

Key words

  • Altitude
  • Mountain sickness
  • Acclimatization
  • Prevention

Intellectual Property

  • 1 patent


  • HP2


  • UGA

Linksium Continuum

  • Commercialization


  • Available licenses


The decrease in oxygenation of the body at high altitude (mountains, aviation, aerospace) causes discomfort and symptoms related to acute mountain sickness AMS, which can evolve into serious pathologies. They are a major concern for people involved in leisure or professional activities.

Current solutions to AMS are complex to implement (oxygen tanks, hyperbaric chamber) or involve the use of medication.


OXUP has developed a concept, scientifically validated by HP2 laboratory, that makes it possible to applicate Positive Pressure Expiration autonomously to raise the SAO2 in a hypoxia situation, without drugs. This innovation consists of a device that imposes resistance to expiration and a specific method of breathing with biofeedback making it possible to increase oxygen transfer from the lungs to the blood.


Difficulties in adapting to altitude, which affect hundreds of thousands of people every year, are a major obstacle to safety and well-being during stays at altitude. The altitude mask developed in this project is an innovative, compact, easy-to-use solution that does not rely on a medicinal principle.

State of progress

A Proof of Concept (PoC) has been validated scientifically and by tests in real conditions by professional experts.


This device will become an invaluable tool either for people performing leisure activities and professionals during high-altitude trips by improving well-being at high-altitudes, either for health by combining innovative inspiratory and expiratory resistances and a biofeedback system imposing appropriate pressures and breathing pattern, the device should provide new opportunities for clinical practice and cares in the field of respiratory diseases.

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